Chitosan-Very High DDA%-Low-Medium Mt. Wt.

Catalog	ACM9012764-53
CAS	9012-76-4
Description	Very High DDA% – Low-Medium Mt. Wt.
Molecular Weight	250-300 kDa
Molecular Formula	(C6H11NO4)n
Appearance	White to light yellow powder
Application	Biocompatible, antibacterial and environmentally friendly polyelectrolyte with a variety of applications including water treatment, chromatography, additives for cosmetics, textile treatment for antimicrobial activity, novel fibers for textiles, photographic papers, biodegradable films, biomedical devices, and microcapsule implants for controlled release in drug delivery.
Storage	<25°C, cool dry environment, well-sealed
Feature	Degree of Deacetylation (DDA) – 98.0%
Form	Powder
Moisture Content	0.061
Packaging	100g, 250g
Particle Size	80 mesh
pH	7.5
Type	Source: Mushroom - Fungal, Non-Animal, Vegetal, Plant-Based Source

Case Study

Rheological Properties of Chitosan-Tripolyphosphate Composite Fluids

Li J, et al. Carbohydrate polymers, 2012, 87(2), 1670-1677.

Chitosan-sodium tripolyphosphate nanoparticles are very useful carriers of drugs and nutraceuticals. To study their rheological properties, composite fluids (nanosuspensions and microgels) crosslinked with chitosan (CS; deacetylation degree 98.0%; Mw:330 kDa) and sodium tripolyphosphate (TPP) were prepared by electrostatic interaction between amino groups of CS and phosphate groups of TPP.
The structural and rheological characteristics of CS-TPP particles were described and the minimum particle size was obtained by the CS/TPP mass ratio of 3.75. The particle size of CS-TPP particles was controlled by chitosan concentration (10 mg/mL and 20 mg/mL) and ultrasonic treatment time (3-9 min, 3.75 W/mL energy output).
The formation of CS-TPP particle suspensions reduced the solution viscosity compared to pure chitosan solutions. During centrifugation, the strong centrifugal force overcame the barrier of electrostatic interactions between CS-TPP particles in the suspension to form CS-TPP microgels. Through the analysis of van der Waals attraction and electrostatic repulsion, combined with DLS and rheological measurements, it was found that large CS-TPP particles are more likely to form tighter microgels than small particles.

Conductive Graphene/Chitosan Hydrogel for Tissue Engineering

Sayyar S, et al. Journal of Materials Chemistry B, 2015, 3(3), 481-490.

A processable conductive graphene/chitosan hydrogel with adjustable swelling properties and excellent biocompatibility was successfully prepared. The hydrogel material can be easily processed into a three-dimensional scaffold by additive manufacturing technology, and fibroblasts show good proliferation, adhesion and viability on the scaffold, indicating that it can be used as a conductive matrix for electrically responsive cell growth in tissue engineering.
Preparation of chitosan graphene films
· In a standard procedure for preparing the composites, medium molecular weight chitosan powder was mixed with an aqueous graphene dispersion to create a 2 % w/v solution. The graphene content (0~3wt%) in the final composite was modified by adjusting the concentration of graphene in the initial aqueous dispersion (CCG). This was followed by the gradual addition of lactic acid while stirring. After stirring for one hour and sonicating for two hours, a homogeneous dispersion was achieved.
· The solution was poured into a petri dish and dried at 50°C. Unbound lactic acid was removed in the wash with a succession of steps in ethanol/phosphate buffered saline (PBS) solutions and the ethanol/PBS ratio was reduced until all was PBS. The samples were then rinsed thoroughly with deionised water and dried in a vacuum oven at 50°C until they lost no more weight.