Chitosan Fiber, Medical Grade

Catalog	ACM9012764-39
CAS	9012-76-4
Synonyms	beta-(1,4)-2-Amino-2-deoxy-D-glucose;
Molecular Formula	(C6H11NO4)n
Appearance	White Powder
Elongation	10±3%
Feature	Anti-Pilling, Abrasion-Resistant, Flame Retardant, Anti-Distortion
Length	38mm±2mm
Moisture Content	15%±1%
pH	6.5~8.0
Specification	1.6dtex-2.0dtex
Type	Staple
Viscosity	50 mpa.s-800 mpa.s

Case Study

Electrospun Chitosan Fibers for Wound Care

Sapkota S, et al. Journal of biomaterials, 2020, 4(2), 51.

Numerous studies have reported electrospun fibrous wound dressings composed of combinations of chitosan and/or polyethylene oxide (PEO) and/or polyvinyl alcohol (PVA) fibers. Because of the rigid molecular matrix nature of chitosan, the more chitosan in the fibers, the stronger the mechanical integrity of the fiber mat. Further, chitosan is highly biocompatible and has cationic polyelectrolyte (anti-inflammatory and antimicrobial) activity with typical wounds.
· Case 1: Fiber scaffolds composed of chitosan-PEO, fibrinogen and chitosan-PEO/fibrinogen had fiber diameters between 200 and 350 nm. When cells were cultured on these fibers infused with carrier-free recombinant human platelet-derived growth factor-BB (rhPDGF-BB), the viability of human dermal fibroblasts varied several-fold over 3 days of culture. To be specific, the cell viability of fibrinogen fibers was around 75% and that of chitosan-PEO/fibrinogen fibers was about 50% - 70%.
· Case 2: Tetracycline hydrochloride (TCH) an antimicrobial drug used to cure several infections (5% wt/wt%) loaded into electrospun PVA/chitosan fibers for controlled antimicrobial drug delivery. TCH released burst-like in vitro - 75% total release within 3 h and plateaued-out at 80 % total release within 24 h.

Chitosan Fibers Improve Mechanical Properties of Chitosan-Based Heart Valve Scaffolds

Albanna M Z, et al. Journal of the mechanical behavior of biomedical materials, 2012, 5(1), 171-180.

This work investigated the effectiveness of chitosan fiber reinforcement methods to improve the mechanical properties of chitosan stents. The leaflet tensile strength value of the fiber-reinforced heart valve stent was 220±17 kPa, which is comparable to the radial value of the human pulmonary valve leaflet. In addition, it was found that 2 mm fibers were three times more effective than 10 mm fibers at the same mass ratio.
Formation of chitosan fiber-reinforced chitosan scaffolds
· Porous chitosan heart valve scaffolds were produced by filling a silicone tri-leaflet mold with 6 ml of 2 wt% MMW chitosan dissolved in 1 vol.% acetic acid. The freezing process began by applying liquid nitrogen to the ventricular side of the mold leaflets for 5 minutes, followed by immersion of the entire mold in a dry ice-isopropanol bath for 3 hours. The frozen structure was then lyophilized overnight.
· Chitosan disc scaffolds was prepared by putting 9 ml of chitosan solution into 35 mm Petri dishes, storing them in a dry ice-isopropanol bath for 3 hours, and lyophilising overnight. Disc scaffolds made of fibers were produced in four fiber/scaffold mass ratios (0, 0.2, 0.3 and 0.4 in dry weight) by random distribution of chitosan fibres (2 or 10 mm long) throughout the chitosan solution before freezing. For the fiber-reinforced heart valve scaffolds prepared at a fiber/scaffold mass ratio of 1.0, 2 mm fibers were first randomly placed in the empty mold, followed by a slow addition of chitosan solution at the bottom using an 18-gauge needle. The chitosan fibers were held in place during the silicone mold filling due to physical entrapment and electrostatic charge effects.